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These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005

Drugs that reduce hepatic blood flow (e.g., propranolol, a -blocker) can decrease their own clearance

Both peptides are generally considered safe when prescribed and monitored by a medical provider

No accumulation occurs with repeated dosing